Mewgenics Best Mutations: Every Mutation Ranked and How to Get Them

Mewgenics has 47 mutations spread across 10 body part slots, and the game tells you almost nothing about which ones are worth breeding for. Here’s every mutation ranked from broken to useless, with practical advice on how to farm the ones you want.

Also a Pokemon Go player? We just published two deep guides for trainers: Best Pokemon Go Accessories covers power banks, phone mounts, gloves, and everything else you need for long sessions. And our Best Auto Catchers guide ranks every Bluetooth catcher on the market.

How mutations work

Mutations are permanent traits tied to a specific body part: arms, body, ears, eyes, eyebrows, fur, head, legs, mouth, or tail. Each slot holds one mutation. A fully mutated cat carries up to 10 at once, and every single one passes down through breeding.

You get mutations four ways:

• Furniture with the Mutation room stat causes cats to develop random mutations overnight. Higher stat means more mutations per night.
• Random events during adventures can permanently mutate a cat. These tend to give strong effects with no tradeoffs.
• Certain items trigger mutations, sometimes when a cat falls in battle. Running fragile cats into danger on purpose is a legit strategy.
• High Appeal attracts stray cats, and some arrive pre-mutated.

Mutations inherit through breeding. High Stimulation in your breeding room increases the chance that kittens get their parents’ mutations rather than losing them. If you want the full breakdown on stat inheritance and room optimization, our beginner guide and house guide cover those systems in depth.

⚡ Genetics note: Mutations follow dominant/recessive rules. A cat can carry a mutation invisibly (Aa genotype) and pass it to offspring. Two carriers have a 25% chance of producing a kitten with that mutation expressed. This means a “clean” looking cat might be hiding exactly what you want.

S-Tier: The broken ones

These mutations change how you play. If you’re breeding endgame cats and they don’t have at least two of these, you’re leaving damage on the table.

Mutation	Slot	Effect	Why it’s S-Tier
Pikachu Tail	Tail	Movement becomes shadowstep (teleport)	Ignore terrain, walls, and enemy zones. Teleport behind anyone for free backstabs. The single best mobility tool in the game.
Dice Eyes	Eye	Gain a random stat buff at the end of each turn	Free scaling every turn with no downside. By turn 5 you’ve stacked multiple stat boosts. By turn 8 you’re a monster. Broken on long fights.
Exhaust Pipe	Tail	+1 Speed each turn	Speed determines turn order and movement range. By turn 3 you’re acting before everything. By turn 6 you’re untouchable. Stacks with Speed gear.
Pointy Ears	Ear	Heal 1 HP per basic attack hit	Passive sustain on every attack. Fighters and Monks (who attack twice) get absurd mileage. Keeps your frontline alive without a Cleric.
Rat Mouth	Mouth	Basic attack inflicts Poison	Free poison on every swing. Poison ticks every turn, ignoring armor. Fighters applying poison while dealing full melee damage is unfair.
Bear Leg	Leg	+1 STR, +1 CON	The only mutation with pure upside and zero downside. Two free stat points on your most important combat stats. Every melee cat wants this.

If I had to pick just two: Pikachu Tail and Dice Eyes. Pikachu Tail solves positioning permanently. Dice Eyes solves scaling permanently. Everything else is optimization on top of those two.

Pikachu Tail and Exhaust Pipe compete for the tail slot. You can’t have both on the same cat. For most builds, Pikachu Tail wins because teleportation is harder to replicate than speed. But on a pure speed-stacking Thief build, Exhaust Pipe pulls ahead since you’re already getting mobility from SPD alone.

A-Tier: Always valuable

Not game-breaking, but you’d never be unhappy to see these on a kitten. Strong enough to build around, and most work on any class.

Mutation	Slot	Effect	Notes
Spider Eyes	Eye	+5% crit chance	Stacks with Double Eyes for 10% total. Crit builds with multi-hit weapons can chain kills. Pairs well with Luck gear.
Double Eyes	Eye	+5% crit chance	Same as Spider Eyes. Both occupy the eye slot, so you pick one or the other. You can’t stack them on the same cat.
Wings	Arm	+2 SPD, fly away when hit	The escape triggers automatically. Gets your casters out of melee range when enemies close in. +2 SPD is solid on top.
Melting	Leg	+5 dodge chance	Flat dodge with no downside. Stack with grass tiles (50% dodge) and you’re nearly unhittable. Great on Thieves.
Axolotl Gills	Ear	Basic attacks create water tiles	Water tiles enable Gills regen, conduct electricity to groups, and extinguish fire. One cat with this controls the battlefield.
Snake	Leg	Basic attack forces target to face away	Turns every basic attack into a backstab setup for your next cat. +25% bonus damage on every follow-up hit.
Lightning Rods	Ear	Electric immunity	Lets you spam chain lightning without worrying about friendly fire. Also trivializes lightning-heavy zones.
Extra Eyes	Eyebrow	+1 Range	Free range on a slot nobody else wants. Hunters and Mages get more value per range point than anyone.
Long Neck	Head	+1 Range	Same benefit as Extra Eyes, different slot. Ideally you run both for +2 total range on your ranged cats.

The range mutations (Extra Eyes + Long Neck) deserve special attention. +2 range on a Hunter or Mage means you’re hitting enemies before they can reach you. Combined with the Sniper + Overwatch synergy from our ability guide, ranged cats become untouchable artillery platforms.

B-Tier: Solid picks

Good mutations with meaningful tradeoffs. Worth keeping when they show up, but not worth farming specifically unless you’re building around them.

Mutation	Slot	Effect	Notes
Thick	Eye	+3 INT, -1 STR, -1 DEX	Best raw stat mutation for casters. The -1/-1 doesn’t matter on a Mage who never swings a weapon.
Blobby Tail	Tail	+2 STR, -1 CHA	Solid melee boost. CHA loss hurts mana pool, so keep this on Fighters and Butchers who don’t rely on spells.
Tongue	Mouth	+2 CON, -1 SPD	More HP is always welcome. Speed loss stings but Tanks don’t need to go first anyway.
Bat Ears	Ear	+2 CON, -1 STR	Tanky mutation for support classes. Clerics and Druids don’t need STR.
Underbite	Mouth	+2 CHA, -1 LCK	More mana for casters. LCK loss reduces crits, so avoid on Hunters.
Socks	Arm	Ice immunity	Niche but unbeatable in ice zones. Completely ignores freeze and slow effects.
Tentacle	Arm	Knockback immunity	Keeps your frontline planted. Great on Tanks and Monks who need to hold position.
Fin	Leg	Free water tile movement	Situational but strong on water-heavy maps. Pairs with Axolotl Gills for water tile strategies.
Gills	Mouth	+2 HP regen while wet	Requires water tiles to function. With Axolotl Gills creating water, this becomes passive +2 HP per turn.
Bat Wings	Arm	Jump movement + Bruise on basic attack	Jump ignores terrain obstacles. Bruise debuff stacks with other damage effects.
Buff	Leg	+1 STR	Simple, clean, no downside. Bear Leg is strictly better since it gives +1 CON too, but if you already have Bear Leg, this stacks in a different slot.

C and D-Tier: Situational to useless

These mutations either require specific setups to work, or just aren’t worth the body part slot.

Mutation	Slot	Effect	Tier	Verdict
Reflective Eyes	Eye	10% reflect projectiles	C	Too unreliable at 10%. If it were 25% it’d be A-tier. Right now it’s a coin flip that rarely pays off.
Bandage	Leg	+1 LCK each time you’re hit	C	Requires getting hit repeatedly. Tanks might benefit but they’d rather just not take damage. Win-more on the wrong end.
Cat Face Face	Mouth	+2 LCK, -1 CON	C	Luck is the best late-game stat, but losing CON on a crit-fishing build makes you fragile. Works on backline Hunters only.
Upside Down Cross	Eyebrow	+2 damage when ally dies	C	Requires your team to die. If your allies are dying regularly, you have bigger problems than +2 damage.
Blood Tears	Eye	Start Bleeding, gain charge when damaged	C	Starting every fight bleeding is rough. The charge mechanic can be built around, but the cost is steep.
Needle	Eye	+1 Thorns	D	1 damage to attackers. Takes the eye slot that could have Dice Eyes or Spider Eyes. Not worth it.
Gold Tooth	Mouth	5-10 coins when downed	D	You get coins when your cat falls. If you’re farming coins, there are better ways. Takes the mouth slot from Rat Mouth.
Pointy	Mouth	1% instakill on basic attack	D	Sounds fun, almost never triggers. 1% per hit means you’d need 70 swings for a coin-flip chance. Just deal more damage instead.
Stretched Tail	Tail	+1 SPD	D	Occupies the tail slot that could have Pikachu Tail or Exhaust Pipe. +1 SPD is not worth that opportunity cost.

The remaining mutations I haven’t listed (Bandaged Arm, Car Tire Arms, Human Ears, Bent Ears, W Eyes, Crescent Eyes, Human Eyes, Triangle Head, Stick Legs, Hairy Body/Fur variants) are all C-tier. They give minor stat bumps with minor tradeoffs. Fine if they show up on a kitten, not worth chasing.

Birth defects worth keeping

Inbreeding produces birth defects. These are negative mutations that occupy the same body part slots as positive ones. Most are garbage. A few are worth tolerating or even building around.

Defect	Slot	Effect	Why it’s usable
Duck Leg	Leg	-2 SPD, water immunity	Water immunity lets your cat stand in water for free Gills regen, ignore water-based attacks, and use electrified water zones as safe ground. The SPD loss matters less on Tanks.
Conjoined Twin	Head	+2 INT, -3 CHA	+2 INT is real value for mana regen. The -3 CHA is brutal on mana pool, but if you’re stacking CHA from other sources, a Mage can absorb it.
Bent Leg	Leg	Trample (damage when moving through tiles)	Free damage during movement. Pairs with high-mobility builds. Thieves with Pikachu Tail can trample through enemies while teleporting.
Conjoined Body	Body	+2 CON, -3 SPD	+2 CON on a Tank who already has low Speed priorities. Not ideal, but if you’re already slow, the extra HP is welcome.

Everything else from inbreeding is pure downside: No Mouth blocks consumables, Red Eyes gives accumulating miss chance, Floppy Ears starts you immobilized, Inward Eyes starts you confused. Avoid. If you want the details on managing inbreeding risk, the “One and Done” rule is covered in our beginner guide: inbreed one generation to lock a trait, then immediately breed out with an unrelated stray.

How to farm mutations: the three-room system

The biggest mistake new players make is cranking the Mutation stat in their breeding room. This creates “mutation pollution,” where kittens are born with random unwanted mutations competing with the ones you’ve been carefully breeding for. Instead, separate the two processes entirely.

Room 1: The breeding room

High Comfort (for breeding frequency) and high Stimulation (for inheriting the better parent’s stats and mutations). Zero Mutation furniture. This room is for passing down what you’ve already collected, not for generating new mutations. Keep your best breeding pairs here. Our breeding guide covers how to optimize this room for multi-generational stat stacking.

Room 2: The mutation lab

High Mutation stat (5-15 range) with a totem or other mechanism to prevent breeding. Cats in this room accumulate random mutations overnight without producing unwanted kittens. Move promising cats here after birth, let them cook for a few nights, then check what mutations they picked up. If they got something good, move them to Room 1 for breeding.

Room 3: Recovery

High Health stat. Heals injuries and cures diseases overnight. Cats coming back from adventures go here first. This room keeps your gene pool healthy. Sick cats breed poorly and can spread disease to your breeding pairs.

⚡ Mutation inheritance tip: Each mutation has a base 50% chance to pass down when only one parent carries it. Higher Stimulation increases this: roughly 55% at 20, 67% at 100, and 75% at 200. This means with 6 mutations on two parents, a kitten might inherit 3-4 of them. Breed multiple litters and select the best results each generation. It takes patience, but after 4-5 generations you can have cats with 8+ targeted mutations.

For the full room setup including furniture recommendations, check our house guide.

Best mutations by class

Different classes want different things from their mutations. Here’s what to prioritize when breeding cats for specific roles. For full class breakdowns, see our class tier list.

Role	Priority Mutations	Why
Fighter / Butcher	Bear Leg, Rat Mouth, Pointy Ears, Snake, Blobby Tail	Raw STR, poison on hit, self-healing, backstab setups. These classes live in melee and need to hit hard while staying alive.
Mage / Druid	Thick, Dice Eyes, Extra Eyes, Long Neck, Underbite	INT for regen, CHA for mana pool, range for safe casting. Dice Eyes scaling is strongest on casters who stay alive long enough to stack buffs.
Tank / Necromancer	Pointy Ears, Bear Leg, Tongue, Bat Ears, Melting	CON stacking, passive healing, dodge. Tanks want to absorb hits. Pointy Ears turns that into a sustain engine.
Thief / Hunter	Pikachu Tail, Spider Eyes, Exhaust Pipe, Melting, Snake	Mobility, crits, dodge. Thieves teleport behind targets for backstab damage. Hunters want range + crit to delete from distance.
Cleric / Psychic	Wings, Extra Eyes, Long Neck, Axolotl Gills, Lightning Rods	Escape tools, range for safe positioning, terrain control. Supports die fast when caught in melee. Wings auto-escape + range mutations keep them safe.
Monk	Pointy Ears, Rat Mouth, Bear Leg, Pikachu Tail, Dice Eyes	Monks attack twice per turn. Anything that triggers on basic attacks (healing, poison, backstab setup) gets doubled.

Monks deserve a callout. Because they attack twice, mutations like Pointy Ears (heal 2 HP per turn instead of 1) and Rat Mouth (double poison application) become twice as good. If you’re building a team comp around a Monk carry, prioritize on-hit mutations above all else.

Gear for cat people

If you’re deep enough into Mewgenics to be optimizing mutation bloodlines, you’re probably spending a lot of hours in front of a screen. Here are some picks for long sessions.

8BitDo Pro 2 has the best d-pad for tactics games at this price. ZOMOPLUS Cat Paw Keycap is a cheap way to rep the cat life on your keyboard. And the SOMIC G951 has RGB cat ears and a mic that doesn’t sound like a tin can. Worth it for the aesthetic alone. For a deeper look at controllers, check our 8BitDo Ultimate 2C review.

Frequently asked questions

Prices on gaming peripherals and accessories change constantly. Berry Finds tracks real-time Amazon deals across thousands of products so you can grab gear at the lowest price.

Summary

47 mutations, 10 body part slots, and a genetics system that rewards patience. The short version: get Pikachu Tail for teleportation, Dice Eyes for infinite scaling, Bear Leg for free stats, and Pointy Ears for sustain. Farm mutations in a dedicated room away from your breeding pairs. Breed multiple litters per generation and be ruthless about which kittens make the cut.

For more Mewgenics strategies, check out our best team comps, class tier list, and ability synergies guide.